For the disks, you may have a small issue with having multiple types of disks in a single RAID10, as those disks might have slightly different physical attributes. ZFS is an option here as you can add two vdevs for the different drive types and add them to the same zpool, which effectively creates the RAID10 you’re looking for. You would typically not use LVM on top of ZFS but if you go with RAID10 it would let you create logical partitions that can be expanded easily at a later time.

Another ZFS option is to use RAIDZ1 with the 4 disks in a vdev. The vdev will use 1 disk of space across all disks to maintain a parity with the other disks. You will have 12TB of usable storage on your 16TB raw storage. This will allow you to lose one drive with no data loss.