Like others said, definitely consider using Jupyter Notebooks for development (note: not necessarily JupyterLab, just Notebooks - multiple IDEs like VSCode support them).

For an actual GUI, I would recommend considering some web dashboard frameworks like Streamlit, Dash or Gradio if you are not felling like spending too much time organizing the layout and making it pretty.

Other than that, I would also recommend taking a look at a few plotting libraries other than matplotlib like Bokeh or Plotly.