I will be running Truenas scale with ZFS, so will be installing 32GB of memory.

I realize a full size PCI slot would be better, but not really necessary for my application. Both have 6 SATA and two M.2s. I could put a 6 SATA/M.2 adapter in when I need more HDs. I’m really just comparing these two, and I don’t really see any disadvantages to the N100 board.