From what I’ve noticed, yes. Considerably.

I’m not knowledgeable enough to explain why, but something about running Baremetal --> VM --> Docker --> Nextcloud-AIO is massively slower than running Baremetal --> Docker --> Nextcloud-AIO. Hell, Nextcloud-AIO on a Pi4 was running faster than when I put it in a much roomier VM.

Someone tried to explain it to me but all I understood was that the databases don’t like that. Something about nested virtualization restricting performance.

Oddly I didn’t run into the same issue when I ran Nextcloud-AIO off of a Digital Ocean VPS. Not sure what they are doing differently, but that was running just as fast as bare metal.