According to Halioua’s post, breeding large dogs for their size caused elevated levels of IGF-1, a hormone that promotes cell growth. Though this hormone contributes to the animals’ great size, it also hastens their aging. LOY-001 reduces the levels of IGF-1 in large and giant dog breeds, extending healthy life spans.

Would that also cause them to grow to smaller sizes? (I suppose that may depend on whether this drug is administered before or after the dog is full-grown though)