The thing that this perspective doesn’t take into account is hunger. It’s all fine and well to say control your calorific intake, but willpower is a finite and limited resource and if it’s the mechanism used to manage calorific intake it will inevitably fail you. Especially when self-control relies on glucose levels in the blood and the aforementioned willpower is being used to reduce those glucose levels.

In the absence of fructose, fat consumption is controlled through the suppression of hunger by the CCK feedback loop. In the absence of fructose, carb consumption is controlled through the insulin/glucagon feedback loop.

Fructose just gets converted into fatty acids without any control loop, leaving you laden with excess fatty acids and still hungry.

Sucrose, which is sugar, is 50% fructose. So it’s not just Americans with their high fructose corn syrup who are being bombarded with calories that our hunger can’t see, it’s anyone eating foods sweetened with sugar.