For sure, any longer term presence outside orbit will hinge on finding resources. And i don’t think it even matters if we’re able to harvest helium-3 or something that might be worth bringing back, but to be able to use enough resources to make it affordable. Every pound lifted from earth to outside orbit will always be too expensive and local resources much much more affordable. While it starts with shelter and radiation shielding (ie live underground), we’ll need to generate bulk consumables like water, oxygen, fuel, and we’ll need to grow at least some of our own food

But we don’t even know if we can live on the moon. Microgravity has bad long term health effects such that we really don’t want to spend more than a year there. Does the moon have enough gravity to be substantially better?

If we do establish a larger off earth presence, we’ll have to compromise on enough gravity for long term health and livability vs as little gravity as necessary to keep space accessible