SSRIs and the like will mess with shrooms. It varies by person, like all this stuff, but you generally need like twice as much. On meds, I got a nice high out of 4.5g. Off meds, I get hit harder than that from 2g. Shroom potency also varies a lot, so it’s not that odd to just have a dud.

Edibles took me several tries to feel anything, but did eventually just start working. They don’t for some people, so that is possible, but it could just take a few tries. I think it was 4-5 for me.