It certainly depends. I’m not sure what qualifies as “most people” now. Plenty of people have higher interest rates on their homes from recent purchases than those who’ve purchased homes 4 or 5 years ago, and if you live in a state with higher income tax you’ll have more to deduct. Also self-employed contractors and non-incorporated small business owners are likely going to itemize. My wife and I itemize but we’re fortunate enough to be in a place where we support a lot of charities so itemization is worth it.