Regardless of which e-mail service you end up using, I find that an incredible simple rule to filter all e-mail with the word “unsubscribe” in it’s body to another folder saves your sanity. It’s still a folder you should go through a few times a week to read all the newsletters and shit you’re subscribed to, and sometimes the occasional false positive, but your inbox will mostly contain e-mail you actually want to read. I have another rule that filters mail from specific senders that I want to read immediately to my Inbox before it hits the unsubscribe rule, but those exceptions are uncommon enough (I only have 7 after years of doing this) to not take much work.