Research what different routes there are to take. Pick one you like. Try to set it up without depending on it just yet. Learn from your mistakes, and what drawbacks you find. Reevaluate your choices and pick another (mabye even on different storage, and do it all again. I bet most selfhosters go trough a few different setups till landing on a favorite. For me, its cosmos-server at home, and a fairly vanilla containeraized treafik setup for my vps.