TrueNAS supports cloud backups on a schedule to Backblaze; easy to setup, failure alerts. Then with Syncthing or the like you can have a 2nd copy of data on another computer.

I keep anything of importance replicated to most of my devices all the time (photographs are on laptop, server, phone, documents on all three and a media machine encrypted with version history). Then the server does snapshots for easy data recovery back in time, and a cloud backup nightly to Backblaze for off-site-ness.