Tailscale is WireGuard under the hood, if you didn’t know. It’s an overlay network that uses WireGuard to make the actual connections, and has some very clever “stuff” to get the clients actually to connect, even if behind firewalls without needing port forwarding.

Using WireGuard directly basically just changes the app you use, which may or may not help with your issues. But the connecting technology is the exact same.