Yes!

You can use things like GameHub/GameHub Lite (a community fork which strips the telemetry), or Winlator. This can run far, far more taxing games than just the little indies. Tomb Raider (2013), Halo MCC, Fallout New Vegas, Silksong, Dave the Diver, Hades II and so on. There is tinkering sometimes, but its getting more and more impressive as time goes on.

Its up to you if you want to plan for the future and buy the ‘Max’ version (with more RAM), but for all that’s possible now, the 12GB version (the Pro model) is more than enough.

It will 100% play small indie games, but remember some games are weird. They’re fickle and refuse to work (I think one of the Deus Ex games refuses to play, I might have read that somewhere?). So it might be a case-by-case basis. If it helps, do a search for AYN Odin 2 (or AYN Odin 2 Portal) + GameHub or Winlator. They share the same chip and have plenty of users sharing their experiences!

Hope this helped :)