Idk if someone from Bethesda said this or if it was just a Youtuber regarding the stupid ways to level up in Oblivion (like jumping around for hours), but: If that‘s how people enjoy playing the game, then let them. And I agree with this.

Regarding abuse if game mechanics and not just bugs/glitches… I can only think of some Dark Souls bosses that can be baited into killing themselves by fall damage. For some it‘s clearly intentional (Iron Guard thing in Dark Souls 1), for some arguable (Dark Souls 2 the guy in the sunken area), and some clearly rather unintended (first real boss in Dark Souls 1 for example, it‘s really hard to do and when it happens the dude drops like a rocket lol)