In that case you would need to add the peers to the wireguard node you have running in the home lab as well. Wireguard can route peer to peer and will take the shortest path available to it.

That said, i highly recommend first getting things working in a “spoke and wheel” style wireguard configuration with either your homelab or the vps as a central peer, then add peers as endpoints after you have everyone with working connections to the central peer. Its just a heck of a lot easier to trouble shoot and get your head around thatway.