If you go old school, Galaxy Express 999 has a universe of extreme inequality where immortal robotized wealthy humans hunt poor people for hunting trophies because they’re so removed from their human origins. The intergalactic train system that the protagonist rides on is an unimaginable luxury, and many plots arise from people trying to steal his train pass in order to escape their own doom or hopelessness. Each planet that they visit is a study in pathos in one form of another, stemming from some human condition or desire.