Matt and Trey really don't give a fuck. They tried to show Muhammed in multiple cartoons, and when the network vociferously shouted them down about it (because it might get them killed or their offices attacked), they snuck him in anyway in multiple places and just didn't tell anyone. When one of the foundational members of their cast didn't want them to trash Scientology, they trashed it ten times harder and told him not to let the door hit him on the ass on the way out. They made out with each other for a long time in "Baseketball."

However valuable or not you feel like their message / their humor is, they are among the very few voices in mainstream media who are simply unafraid and doing their own thing, completely without reservation.