Since Wine 9.0, you can run 32-bit windows apps on 64-bits directly, without the need for 32bits distro support. It’s called WoW64.

You can in some cases, but not all.

There are two forms of WoW64. Old WoW64 uses 32-bit libraries.

New WoW64 (introduced in Wine 9.0) works without 32-bit libraries, but is still incomplete. It cannot yet replace old WoW64 everywhere, and even where it can, it reduces performance in some APIs. (For example, OpenGL.)

It will eventually make sense to drop the old one, but doing so now would be premature.