Comment on Study suggests single dose of psilocybin safe and effective as treatment for major depressive disorder

Branch_Ranch@lemmy.world ⁨1⁩ ⁨year⁩ ago

• roguestew@lemmy.world ⁨1⁩ ⁨year⁩ ago

  25mg of psilocybin, not 25mg dried mushrooms. This isn’t an insignificant dose, roughly equivalent to 2.5g of mushrooms.

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  • Steeve@lemmy.ca ⁨1⁩ ⁨year⁩ ago

    Thanks, was hoping to find this in the comments. That’s actually a much lower than I expected, always thought you had to go on a 5g journey. I personally don’t even get visual hallucinations on 2.5g

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    • June@lemm.ee ⁨1⁩ ⁨year⁩ ago

      Oh damn. That’s getting to the point of tripping right? I’ve been microdosing 500mg of dried mushrooms for a little bit now and have felt some mood stabilization from it but this has me wondering if I should go for a heavy dose and see how it goes.

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      • Steeve@lemmy.ca ⁨1⁩ ⁨year⁩ ago

        I absolutely recommend a 2g dose, it’s just a fun, comfortable, good time for the majority of people. Some people will trip harder than others, but I’ve never met anyone who didn’t enjoy a 2g trip and if you’re already microdosing 500mg without much effect you won’t be going off the rails tripping or anything. I’d consider it a starter dose.

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• Bwaz@kbin.social ⁨1⁩ ⁨year⁩ ago

  25mg of mushroom would be.
  But 25mg of pure psilocybin is more than a microdose.

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  • Branch_Ranch@lemmy.world ⁨1⁩ ⁨year⁩ ago

    Gotcha. I misread it. Thanks!

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• amio@kbin.social ⁨1⁩ ⁨year⁩ ago

  Makes sense as long as it works, a lot of people are not prepared to trip balls anyway, even as part of a treatment. Ketamine (for the same purpose, which is increasingly a thing) has the same issue.

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  • agent_flounder@lemmy.one ⁨1⁩ ⁨year⁩ ago

    Never done drugs but depression is fucking horrible and debilitating. If the price to pay for putting depression on hiatus for a year or two is tripping balls, sign me the fuck up right now. I swear the first second I am retired (and thus can’t get fired for drugs) I am investigating one of these types of treatments. But my understanding is micro dosing is generally the treatment? Idk.

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    • CADmonkey@lemmy.world ⁨1⁩ ⁨year⁩ ago

      Fun fact, a lot of employers don’t test for mushrooms. If it’s a 5 panel test, they don’t test for it at all.

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      • AzuleBlade@lemm.ee ⁨1⁩ ⁨year⁩ ago

        Fun fact, it’s legal to purchase spores and grow kits in the US, since they don’t contain any psilocybin.

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    • amio@kbin.social ⁨1⁩ ⁨year⁩ ago

      I agree and have literally done that exact thing for that exact purpose... but not everyone does.

      My point was just that having a drug that doesn't require tripping balls in a tightly controlled setting is a good idea. Not everyone is up for it (personality, circumstances) and any trip has risks, you need monitoring which takes trained manpower etc. - it's worth it while we have no other treatment, but it isn't very practical for a bunch of reasons.

      Microdosing would be dependent on the chemical. This is supposedly a relatively small dose (or so someone else said, I have no idea about shrooms) but if the study is to be believed, fairly effective anyway.

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