Veeam Backup&Replication with a NFR license for me.
My personal setup:
First backup: Just a back up to a virtual drive stored on my NAS
Offsite backup: Essentially an export of what is available and then creates a full or incremental backup to an external USB drive.
I have two of those. One I keep at home in case my NAS explodes. The second is at my work place.
The off-site only contains my most important pieces of data.
As for frequency: As often as I remember to make one as it requires manual interaction.

Our clients have (depending on their size) the following setups:
2 or more endpoints (excluding exceptions):
Veeam BR Server
First backup to NAS
Second backup (copy of the first) to USB drives (min. of 3. 1 connected, 2 somewhere stored in the business, 3 at home/off-site. Daily rotation)
Optionally a S3 compatible cloud backup.

Bigger customers maybe have mirroring but we have those cases very rarely.