Some of the Isekai I thought was more unique and haven’t been mentioned here already.

So I’m a spider so what?

The Isekai drives the main plot for this one, a class is reincarnated into another world. The anime mainly follows one of the characters who has been turned into a spider monster but also flips to some of the other students who are humans and their teacher who is trying to round them all up to protect them.

The Isekai point is more important later on in the Light Novels (after the anime) as you learn more about the world, what the teacher has been doing over the years and the motives of the most powerful people in the world. If the reincarnations were not introduced into the world it would have gone differently.

No longer allowed in another world

This wasn’t an anime I found particular interesting but I feel it is unique. It follows a writer who has been reincarnated into a world that has lots of other reincarnations already. He ends up using his skills to get rid of reincarnations that are causing havoc on the world.

Another similar anime is The Executioner and her way of life

Miss Kobayashis dragon maid

Reverse Isekai? Dragons coming to earth and living as humans.

A fun anime that shouldn’t be taken serious but is entertaining.