Everything @CondorWonder@lemmy.ca said and because backups to Home Assistant OS also include addons, which is just very convenient.

My Proxmox setup has 3 VMs:

1. Home Assistant OS with all the add-ons (containers) specific to Home Assistant
2. TrueNAS with an HBA card using PCIe passthrough
3. VM for all other services

Also, if you ever plan to switch from a virtualized environment to bare metal servers, this layout makes switching over dead easy.