Lovers in a dangerous space time has been suggested already, so I’ll just mention it as a second vote!

Magicka and Magicka 2 are excellent, and hilarious. Might be a bit hectic later on, but early on both are pretty low stakes and paced slowly.

My other recommendation is Octodad. You control independent limbs of an octopus, pretending to be a man. Multiplayer is couch co-op. Remote play would be tougher, but still very funny!